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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RCL All Species: 12.12
Human Site: Y145 Identified Species: 38.1
UniProt: O43598 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43598 NP_006434.1 174 19108 Y145 S R F Q V W D Y E E G E V E A
Chimpanzee Pan troglodytes XP_518907 121 13295 E93 R F Q V W D Y E E G E V E A L
Rhesus Macaque Macaca mulatta XP_001093715 174 19061 Y145 S R F Q V W D Y E E G E V E A
Dog Lupus familis XP_538931 165 17954 M132 S G R V L S A M I R G A A D G
Cat Felis silvestris
Mouse Mus musculus Q80VJ3 173 18959 Y134 S R F Q V W D Y A E E E V E T
Rat Rattus norvegicus O35820 163 17762 Y134 S R F Q V W D Y A E G E V E T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio B8A556 143 16168 A115 A M I R G A S A K P L F Q V Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001195603 127 14003 I99 P K K L S A M I R G A D G I N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 65.5 94.2 78.7 N.A. 73.5 74.1 N.A. N.A. N.A. N.A. 51.1 N.A. N.A. N.A. N.A. 34.4
Protein Similarity: 100 68.3 95.9 84.4 N.A. 79.8 79.8 N.A. N.A. N.A. N.A. 65.5 N.A. N.A. N.A. N.A. 48.8
P-Site Identity: 100 6.6 100 13.3 N.A. 80 86.6 N.A. N.A. N.A. N.A. 0 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 6.6 100 26.6 N.A. 80 86.6 N.A. N.A. N.A. N.A. 20 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 0 0 0 0 25 13 13 25 0 13 13 13 13 25 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 13 50 0 0 0 0 13 0 13 0 % D
% Glu: 0 0 0 0 0 0 0 13 38 50 25 50 13 50 0 % E
% Phe: 0 13 50 0 0 0 0 0 0 0 0 13 0 0 0 % F
% Gly: 0 13 0 0 13 0 0 0 0 25 50 0 13 0 13 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 13 0 0 0 0 13 13 0 0 0 0 13 0 % I
% Lys: 0 13 13 0 0 0 0 0 13 0 0 0 0 0 0 % K
% Leu: 0 0 0 13 13 0 0 0 0 0 13 0 0 0 13 % L
% Met: 0 13 0 0 0 0 13 13 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % N
% Pro: 13 0 0 0 0 0 0 0 0 13 0 0 0 0 0 % P
% Gln: 0 0 13 50 0 0 0 0 0 0 0 0 13 0 13 % Q
% Arg: 13 50 13 13 0 0 0 0 13 13 0 0 0 0 0 % R
% Ser: 63 0 0 0 13 13 13 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25 % T
% Val: 0 0 0 25 50 0 0 0 0 0 0 13 50 13 0 % V
% Trp: 0 0 0 0 13 50 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 13 50 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _